Hair loss and the development of skin wrinkles are aspects that we all know more or less as we get older. These symptoms of aging are largely dictated by the decline of mitochondrial function within cells. Researchers have succeeded in reversing this process in mice.
News from the latest research
A new, groundbreaking study by researchers at the University of Alabama in Birmingham, UK, has shown that inversion of mitochondrial dysfunction in mice can reverse hair loss and smooth out their wrinkles. . The research points to new targets that scientists must study to develop treatments for skin deterioration and age-related hair loss.
Mitochondria at the heart of the problem
For some time, researcher has brought about new facts that show the between aging and a decrease in mitochondrial function. The depletion of the mitochondrial genome (mtDNA) has been implicated in a number of human diseases, such as neurodegeneration, cancer, and even diabetes.
According to research, a human loses four copies of mtDNA every 10 years. The question of whether this decrease in mtDNA is causally related to age-related diseases is still debated, but this new study demonstrates for the first time that mtDNA restoration can to improve a number of physiological conditions related to age.
The mouse model
The new study began with the development of a mouse model in which mtDNA can be depleted with a simple stimulating antibiotic. At the age of 8 weeks, the mice received the triggering antibiotic, which resulted in a subsequent decrease in mtDNA. Within four weeks, the mice showed hair loss, wrinkled skin and lethargy, signs of natural aging, albeit in an accelerated manner.
More importantly, when the antibiotic trigger was removed, the researchers witnessed an impressive reversal of these physiological signs, including a thick regrowth of the hair and a smoothing of all the wrinkles in the skin.
This dramatic turnaround surprised researchers, the study suggesting for the first time that mtDNA could be an effective regulator of skin aging and hair loss.
The study did not examine the broader systemic implications of this specific type of mtDNA depletion and restoration, but initial investigations found little change in other animal organs, suggesting that mitochondria play a very important role in the skin compared to other tissues of the body.
Of course, there is still a lot of research to be done before this discovery leads to human treatment, but if this direct mechanism can be replicated in humans and modulated effectively, it could offer a future where we can reduce physiological degeneration including age-related conditions such as wrinkles and hair loss.
According to this research;
This mouse model is expected to provide an unprecedented opportunity for the development of preventive and therapeutic drug development strategies to increase mitochondrial functions for the treatment of skin and hair pathologies associated with aging and other human diseases in humans – which mitochondrial dysfunction plays an important role.
This mouse model should offer an unprecedented opportunity for the development of preventive therapeutic strategies to increase mitochondrial functions for the treatment of skin and capillary pathology associated with aging and other human diseases in which mitochondrial dysfunction plays a role.